Chronobiology Revisited in Psychiatric Disorders: From a Translational Perspective

• 발행기관: 대한신경정신의학회
• 저자명: Simge Seren Kirlioglu Yasin Hasan Balcioglu
• 간행물 정보: 『Psychiatry Investigation』제17권 제8호, 725~743쪽, 전체 19쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2020.08.31

영문 초록

Objective Several lines of evidence support a relationship between circadian rhythms disruption in the onset, course, and maintenance of mental disorders. Despite the study of circadian phenotypes promising a decent understanding of the pathophysiologic or etiologic mechanisms of psychiatric entities, several questions still need to be addressed. In this review, we aimed to synthesize the literature investigating chronobiologic theories and their associations with psychiatric entities. Methods The Medline, Embase, PsycInfo, and Scopus databases were comprehensively and systematically searched and articles published between January 1990 and October 2019 were reviewed. Different combinations of the relevant keywords were polled. We first introduced molecular elements and mechanisms of the circadian system to promote a better understanding of the chronobiologic implications of mental disorders. Then, we comprehensively and systematically reviewed circadian system studies in mood disorders, schizophrenia, and anxiety disorders. Results Although subject characteristics and study designs vary across studies, current research has demonstrated that circadian pathologies, including genetic and neurohumoral alterations, represent the neural substrates of the pathophysiology of many psychiatric disorders. Impaired HPA-axis function-related glucocorticoid rhythm and disrupted melatonin homeostasis have been prominently demonstrated in schizophrenia and other psychotic disorders, while alterations of molecular expressions of circadian rhythm genes including CLOCK, PER, and CRY have been reported to be involved in the pathogenesis of mood disorders. Conclusion Further translational work is needed to identify the causal relationship between circadian physiology abnormalities and mental disorders and related psychopathology, and to develop sound pharmacologic interventions.

목차

INTRODUCTION

MOLECULAR REGULATION OF THE CIRCADIAN RHYTHM

NEUROHUMORAL AND HORMONAL REGULATION OF CIRCADIAN RHYTHM

CIRCADIAN RHYTHM AND ITS IMPLICATIONS ON PSYCHIATRIC DISORDERS

CONCLUSION

REFERENCES

키워드

Biological clocks Circadian rhythm disorders Mental disorders Melatonin HPA-axis