Biomarkers in Drug Free Subjects with Depression : Correlation with Tryptophan

• 발행기관: 대한신경정신의학회
• 저자명: Noreen Samad Farzana Yasmin Natasha Manzoor
• 간행물 정보: 『Psychiatry Investigation』제16권 제12호, 948~953쪽, 전체 6쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2019.12.31

영문 초록

Objective: Depression is a prevalent condition that is costly to individuals and society. In view of a role of tryptophan (TRP), selenium (Se), vitamin D (Vit D), magnesium (Mg) and serotonin in depression, the present study concerns to evaluate the circulating levels of TRP, Se, Vit D, Mg and serotonin in depression as well as the correlation between TRP and other serum analytes is also established. Methods: Healthy (n=48) and depressed (n=48) subjects were recruited and their blood samples were obtained after an overnight fast of 12 h, serum was stored for the determination of levels of TRP, Se, Vit D, Mg, and serotonin. Results: show that levels of TRP, Se, Vit D, Mg, and serotonin were decreased in the depressed patient when compared to normal subjects. There is a direct correlation between TRP and Vit D, and TRP and Se while the inverse correlation between TRP and Mg, and TRP and serotonin in depressed subjects. The association among TRP and other biomarkers is non-significant. Conclusion: In conclusion, depression is associated with deficiency of TRP, Se, Vit D, Mg, and serotonin displays the characteristics of biomarkers. The correlation between TRP and other biomarkers/trace elements is also important in depression.

목차

INTRODUCTION

METHODS

RESULTS

DISCUSSION

키워드

Depression Tryptophan Selenium Vitamin D Serotonin Magnesium Trace elements Biomarkers