뇌의 REM 수면 발생기전

• 영문명: Brain Mechanisms Generating REM Sleep
• 발행기관: 대한수면의학회
• 저자명: 손진욱
• 간행물 정보: 『수면정신생리』제2권 제2호, 133~137쪽, 전체 5쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1995.12.31

영문 초록

The author reviews current knowledge about what REM sleep is and where and how it is generated. REM sleep is the state in which our most vivid dreams occur. REM sleep is identified by the simultaneous presence of a desynchronized cortical EEG, an absence of activity in the antigravity muscles(atonia), and periodic bursts of rapid eye movements. Another characteristic phenomena of REM sleep are the highly synchronized hippocampal EEG of theta frequency and the ponto-geniculo-occipital(PGO) spike. All these phenomena can be explained in terms of changes in neuronal activity. Transection studies have determined that the pons is sufficient for generating REM sleep. Lesion studies have identified a small region in the lateral pontine tegmentum corresponding to lateral portions of the nucleus reticularis pontis oralis(RPO) and the region immediately ventral to the locus coeruleus, which is required for REM sleep. Unit recording studies have found a population of cells within this region that is selectively active in REM sleep. Cholinergic neurons of the giant cell field of pontine tegmentum(ETG), which is REM a sleep-on cells , has shown to be critically involved in the generation of REM sleep. Noradrenergic neurons of the locus coeruleus and serotonergic neurons of the dorsal raphe, which are called REM sleep-off cells , appear to act in a reciprocal manner to the cholinergic neurons. It is proposed that the periodic cessations of discharge of REM sleep-off cells during REM sleep might be significant for the prevention of the desensitization of receptors of these neurons.

목차

서론

REM 수면이란 무엇인가?

REM 수면은 어디서 만들어지는가?

종합

키워드

REM 수면 해마 theta 파 PGO spike 뇌교 아세틸콜린 세로 토닌 REM sleep Hippocampal theta PGO spike Pons Acetylcholine NE Serotonin