진성 성조숙증 및 조기 사춘기를 가진 남아에서 성선 자극 호르몬 방출 호르몬 작용제 치료 효과

• 영문명: Effect of gonadotropin-releasing hormone agonist treatment in boys
• 발행기관: 조선대학교 의학연구원
• 저자명: 조아영(Ah Young Cho) 이재희(Jae Hee Lee) 김은영(Eun Young Kim)
• 간행물 정보: 『The Medical Journal of Chosun University』제44권 제2호, 87~93쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2019.10.30

영문 초록

Central precocious puberty (CPP) is less common in boys than girls; very little data is reported on effect of gonadotropin-releasing hormone analog (GnRHa) treatment in boys with CPP. The aim of the study was to evaluate growth changes in boys with CPP and early puberty (EP) treated with GnRHa therapy for 1 year. In 60 (39 CPP and 21 EP) boys with confirmed diagnosis of CPP and EP, auxological [height, height standard deviation score (Ht SDS), bone age (BA), Predicted adult height (PAH)] and endocrinological parameters were obtained at baseline, at 6 months, and at 1 year after GnRHa treatment in boys with CPP and EP. During the treatment a decline in Ht SDS and growth velocity, luteinizing hormone (LH), follicle stimulating hormone (FSH) and testosterone levels were observed (p＜0.01); and a deceleration in the maturation of bones after 1 year GnRHa treatment was observed (p＜0.01). PAH SDS was increased during treatment with GnRHa (p＜0.01). There was significant difference in PAH SDS between organic CPP and non-organic CPP (p＜0.05). The present data indicate that GnRHa therapy significantly improves growth prognosis in boys with CPP and EP.

목차

서론

대상 및 방법

결과

고찰

키워드

Central precocious puberty Gonadotropin releasing hormone Height