알츠하이머 치매에서 수면구 조 및 일주기리듬의 변화

• 영문명: Alternation of Sleep Structure and Circadian Rhythm in Alzheimer’s Disease
• 발행기관: 대한수면의학회
• 저자명: 손창호(Chang-Ho Sohn)
• 간행물 정보: 『수면정신생리』제9권 제1호, 9~13쪽, 전체 5쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2002.06.30

영문 초록

Alzheimer s disease (AD) is one of the most common and devastating dementing disorders of old age. Most AD patients showed significant alternation of sleep structure as well as cognitive deficit. Typical findings of sleep architecture in AD patients include lower sleep efficiency, higher stage 1 percentage, and greater frequency of arousals. The slowing of EEG activity is also noted. Abnormalities in REM sleep are of particular interest in AD because the cholinergic system is related to both REM sleep and AD. Several parameters representing REM sleep structure such as REM latency, the amount of REM sleep, and REM density are change in patients with AD. Especially, measurements of EEG slowing during tonic REM sleep can be used as an EEG marker for early detection of possible AD. In addition, a structural defect in the suprachiasmatic nucleus is suggested to cause various chronobiological alternations in AD. Most of alternations related to sleep make sleep disturbances common and disruptive symptoms of AD. In this article, the author reviewed the alternation of sleep structure and circadian rhythm in AD patients.

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키워드

노인성 치매 수면 렘수면 Alzheimer s disease Sleep Dementia REM sleep