임상에서 시 간약물학

• 영문명: Chronopharmacology in Clinical Medicine
• 발행기관: 대한수면의학회
• 저자명: 이헌정(Heon-Jeong Lee) 김린(Leen Kim)
• 간행물 정보: 『수면정신생리』제11권 제2호, 67~72쪽, 전체 6쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2004.12.31

영문 초록

Circadian rhythm is a global phenomenon, the control mechanisms of which are manifested at every level of biological organization, from genes and intracellular mechanisms to networks of cell populations, and to all central neuronal systems at the organismic level. In pharmacotherapy, the pharmacokinetic parameters such as drug absorption and distribution, drug metabolism, and renal elimination show diurnal variations. The symptoms and signs in diseases like asthma, myocardiac infarction, angina pectoris, hypertension and stroke also show diurnal fluctuations. These observations require drug treatment considering the circadian rhythm of body function and disease. Circadian time has to be taken into account as an important variable influencing a drug s pharmacokinetics and/or its effects or side effects in clinical practice.

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키워드

시간약물학 일주기 리듬 약물치료 Chronopharmacology Circadian rhythm Pharmacotherapy