Period3 유전자다형성과 기분 및 행동 계절성 변동의 연관성

• 영문명: Association of the Period3 Gene Polymorphism and Seasonal Variations in Mood and Behavior
• 발행기관: 대한수면의학회
• 저자명: 이헌정(Heon-Jeong Lee) 강승걸(Seung-Gul Kang) 김린(Leen Kim)
• 간행물 정보: 『수면정신생리』제13권 제1호, 22~26쪽, 전체 5쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2006.06.30

영문 초록

Circadian rhythms have been observed to be disturbed in mood disorders, especially seasonal affective disorder (SAD). Clock related gene variants also have been suggested to be associated with seasonality (seasonal variations in mood and behavior). This study tested the potential association between a length polymorphism of Period3 gene and seasonal variations in mood and behavior. 297 Korean college students were genotyped for the Period3 polymorphism and were for evaluated the seasonal variation by Seasonal Pattern Assessment Questionnaire (SPAQ). The genotype frequencies were 0.76 for 4R/4R, 0.22 for 4R/5R and 0.013 for 5R/5R. The global seasonality score was not different among Period3 gene variants (4R/4R, 4R/5R and 5R/5R) except for sleep length subscore. The 5R/5R genotype showed the higher sleep length subscore than others (p=0.024). The comparison between seasonals (syndromal plus subsyndromal SAD determined by SPAQ) and non-seasonals did not show any significant difference in frequencies of genotypes. These findings suggest that there is a possibility that the investigated Period3 polymorphism may play a partial role in the susceptibility of seasonal variations in a Korean population.

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계절성 유전자다형성 Seasonality Period3 Polymorphism