폐쇄성 수면무호흡 과 제2형 당뇨병

• 영문명: Obstructive Sleep Apnea and Type 2 Diabetes
• 발행기관: 대한수면의학회
• 저자명: 강현희(Hyeon Hui Kang) 이상학(Sang Haak Lee)
• 간행물 정보: 『수면정신생리』제16권 제2호, 61~64쪽, 전체 4쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2009.12.31

영문 초록

Obstructive sleep apnea (OSA) has been definitively shown to be a risk factor for the development of cardiovascular disease and mortality. Recent reports have indicated that obstructive sleep apnea is associated with insulin resistance and impaired glucose metabolism, also have type 2 diabetes. The potential mechanisms leading to the development of type 2 diabetes in OSA patients are likely to be various. Reduced physical activity resulting from daytime somnolence, sympathetic nervous system activation, intermittent hypoxia, sleep fragmentation and sleep loss, dysregulation of the hypothalamic-pituitary axis, alteration in adipokine profiles, and activation of inflammatory pathways have been proposed. Based on the current evidence, clinicians should assess the risk of OSA in patients with type 2 diabetes and, conversely, consider that possibility of glucose intolerance in patients with OSA. Further large-scale and long-term follow-up studies in patient populations with selected by reliable but inexpensive diagnostic measures, controlled for potential confounder factor, are needed.

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키워드

폐쇄성 수면무호흡 제2형 당뇨병 인슐린 저항성 내당능 장애 Obstructive sleep apnea Type 2 diabetes Insulin resistance Glucose intolerance