식물에서 shikimate 및 방향족 아미노산 생합성 경로와 이의 대사공학적 응용

• 영문명: Biosynthetic pathway of shikimate and aromatic amino acid and its metabolic engineering in pl
• 발행기관: (사)한국식물생명공학회
• 저자명: 임선형(Sun Hyung Lim) 박상규(Sang Kyu Park) 하선화(Sun Hwa Ha) 최민지(Min Ji Choi) 김다혜(Da Hye Kim) 이종렬(Jong Yeol
• 간행물 정보: 『Journal of Plant Biotechnology』42권 3호, 135~153쪽, 전체 19쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2015.09.30

영문 초록

The aromatic amino acids, which are composed of L-phenylalanine, L-tyrosine and L-tryptophan, are general components of protein synthesis as well as precursors for a wide range of secondary metabolites. These aromatic amino acids-derived compounds play important roles as ingredients of diverse phenolics including pigments and cell walls, and hormones like auxin and salicylic acid in plants. Moreover, they also serve as the natural products of alkaloids and glucosinolates, which have a high potential to promote human health and nutrition. The biosynthetic pathways of aromatic amino acids share a chorismate, the common intermediate, which is originated from shikimate pathway. Then, tryptophan is synthesized via anthranilate and the other phenylalanine and tyrosine are synthesized via prephenate, as intermediates. This review reports recent studies about all the enzymatic steps involved in aromatic amino acid biosynthetic pathways and their gene regulation on transcriptional/posttranscriptional levels. Furthermore, results of metabolic engineering are introduced as efforts to improve the production of the aromatic amino acids-derived secondary metabolites in plants.

키워드

Aromatic amino acid Metabolic engineering