항정신병약물의 생물학적 기전 최신 지견

• 영문명: New Insights into the Molecular and Cellular Mechanism of Antipsychotics
• 발행기관: 대한신경정신의학회
• 저자명: 김세현(Se Hyun Kim)
• 간행물 정보: 『신경정신의학』제58권 제1호, 12~17쪽, 전체 6쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2019.02.28

영문 초록

The serendipitous discovery of drugs with antipsychotic action has provided a clue to understanding the pathogenesis of psychotic disorders and to develop so called ‘antipsychotics’ drugs. From the ‘dopamine hypothesis’ to current molecular psychiatry findings, researchers have endeavored to improve the understanding of the mechanism of action of antipsychotic drugs. Signaling molecules were examined as novel intracellular targets of antipsychotic action. The findings regarding the effects of antipsychotics on inflammation, metabolism, and cellular fate have helped conceptualize the biological action of antipsychotics. This review summarizes the current knowledge of the molecular psychiatry findings regarding the action mechanisms of antipsychotics. The accumulation of research findings will lead to a better understanding of the pathogenesis of schizophrenia and its treatment mechanism.

목차

서 론

항정신병약물의 수용체 작용 후 세포 내 신호전달계 연구 현황 및 의의

항정신병약물의 세포 운명에 대한 영향

항정신병약물의 염증 및 대사계에 대한 영향

항정신병약물의 후성유전학 기전에 대한 영향

결 론

키워드

Antipsychotics Psychopharmacology Signal transduction