학술논문
Anti-proliferative Effect of a Novel Anti-oxidative Peptide in Hanwoo Beef on Human Colorectal Carcinoma Cells
이용수 7
- 영문명
- 발행기관
- 한국축산식품학회
- 저자명
- Hye-Jin Kim Se-Ran Yang Aera Jang
- 간행물 정보
- 『Food Science of Animal Resources』Korean Journal for Food Science of Animal Resources 제38권 제6호, 1168~1178쪽, 전체 11쪽
- 주제분류
- 농수해양 > 식품과학
- 파일형태
- 발행일자
- 2018.12.31
4,120원
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국문 초록
영문 초록
The present study aimed to characterise anti-oxidant peptides from water-soluble protein extracts of Hanwoo beef and evaluate their anti-proliferative effect on human colorectal carcinoma cells (HCT116). Antioxidant peptides were purified from the low-molecular-weight fraction (<3 kDa) of Hanwoo beef extract. Antioxidant activity of peptide fractions was determined using the oxygen radical absorbance capacity (ORAC) assay. Purified peptide (P3) displayed higher ORAC activity than the low-molecular-weight fraction (202.66 μM TE/g vs 167.38 μM TE/g of dry matter, respectively)(p<0.05). The peptide sequence of P3 was Cys-Cys-Cys-Cys-Ser-Val-Gln-Lys (888.30 Da). The novel peptide P3, at 250 μg/mL, also significantly inhibited HCT116 cell proliferation up to 25.24% through phosphorylation of ERK, JNK, and p38 kinase (p<0.05). Hence, antioxidant peptide P3 from Hanwoo beef extract can be used as an antioxidative and anti-cancer agent in the functional food industry.
목차
Introduction
Materials and Methods
Results and Discussion
Conclusion
키워드
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