학술논문
Prognostic Significance of p53, Ki-67 and COX-2 in Gastric Cancer
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- 영문명
- Prognostic Significance of p53, Ki-67 and COX-2 in Gastric Cancer
- 발행기관
- 조선대학교 의학연구원
- 저자명
- Su Hyun Kim Won Cheol Park Min Sung Kim Sung Soo Kim Weijie He Young Don Min
- 간행물 정보
- 『The Medical Journal of Chosun University』제42권 제2호, 39~43쪽, 전체 5쪽
- 주제분류
- 의약학 > 기타의약학
- 파일형태
- 발행일자
- 2017.06.30
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국문 초록
영문 초록
The clinical importance of biologic markers remains elusive in gastric cancer. The aim of this study was to evaluate the prognostic value of p53, Ki-67, and COX-2 in gastric cancer. This retrospective study examined based on medical records of postoperative immunohistochemical test of 176 patients who demonstrated high expression of all three biological markers being tested (p53, Ki-67, and COX-2), among 357 gastric cancer patients who underwent surgical resection consecutively. This study demonstrates the correlation with biologic marker between clinical relationship and recurrence free survival (RFS). A positive correlation was observed between the expression of Ki-67 and p53, and a positive correlation was also observed between the expression of Ki-67 and COX-2 Expression of p53 did not correlate with any of the clinicopathological variables examined. Both Ki-67 and COX-2 expression significantly correlated with tumor depth, classified as early gastric cancer and advanced gastric cancer. The expression of COX-2 significantly correlated with tumor differentiation, with more tumors being of the undifferentiated type than of the differentiated type in the COX-2 positive group. A significant difference between p53 and RFS, also COX-2 expression and RFS was observed. This study showed that only p53 and COX-2 have significantly correlated with the RFS of gastric cancer.
목차
Introduction
Materials and Methods
Results
Discussion
Conclusion
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