급성림프구성백혈병에서 최초로 발견된 필라델피아 염색체 3방향전위 t(1;9;22)(p22;q34;q11.2)

• 영문명: Three-way Ph Variant t(1;9;22) Found in a Patient with Acute Lymphoblastic Leukemia
• 발행기관: 조선대학교 의학연구원
• 저자명: 최인선(In Sun Choi) 박 건(Geon Park) 장숙진(Sook Jin Jang) 문대수(Dae Soo Moon) 강성호(Seong Ho Kang)
• 간행물 정보: 『The Medical Journal of Chosun University』제41권 제3호, 88~91쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2016.09.30

영문 초록

Three-way Philadelphia (Ph) variant translocation is rarely found in patients with acute lymphoblastic leukemia. We report a 3-way Ph variant t(1;9;22)(p22;q34;q11.2) which was detected for the first time in acute lymphoblastic leukemia and a combined novel variant t(1;15)(q11;q24). The patient was a 56-year-old woman and was diagnosed with acute lymphoblastic leukemia. Karyotypic analysis showed 46,XX, t(1;9;22)(p22;q34;q11.2),der(15)t(1;15)(q11;q24). t(1;9;22)(p22;q34;q11.2) was reported only in patient with chronic myelogenous leukemia. Additional FISH showed 1q trisomy and supported the accurate detection of der(15)t(1;15)(q11;q24). Further studies are necessary to discover genes involved in development of the novel variant and the significance of the novel variant.

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키워드

Acute lymphoblastic leukemia Three-way Philadelphia translocation Variant t(1 15)