Acute Kidney Injury following Low Dose Mannitol Infusion

• 영문명: Acute Kidney Injury following Low Dose Mannitol Infusion
• 발행기관: 조선대학교 의학연구원
• 저자명: You Suk Kim Yun Jae Kwon Jin Dong Kim You Jung Lee Eun Seo Lee Yu Ji Lee
• 간행물 정보: 『The Medical Journal of Chosun University』제40권 제2호, 37~39쪽, 전체 3쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2015.06.30

영문 초록

Mannitol is commonly used to reduce intracranial and intraocular pressures and to prevent dialysis-disequilibrium syndrome. However, intravenous mannitol infusion in various cases has the potential to result in acute kidney injury (AKI). We present a case of mannitol-induced AKI that developed after low dose mannitol infusion and resulted in recovery after hemodialysis. A 66-year-old woman was admitted to the hospital with a diagnosis of left middle cerebral artery infarction. On hospital day 5, cerebral edema was observed on a follow-up MRI. D-mannitol 35 g was given intravenously every 8 hours. Four days later, serum creatinine levels were elevated from 1.2 mg/dL to 3.5 mg/dL. The serum osmolal gap was found to be 52.4 mosm/kg H₂O and urine output was reduced from 2.78 mL/kg/h to 0.69 mL/kg/h over three days. Hemodialysis over 2 hours was performed and renal function subsequently improved to baseline function. A potential risk of AKI exists even with low dose mannitol infusion in patients with advanced age, underlying renal impairment, and concomitant use of nephrotoxic agents. Mannitol-induced AKI may be rapidly reversed by short-term hemodialysis.

목차

Introduction

Case report

Discussion

키워드

Acute kidney injury Cerebral infarction Hemodialysis Mannitol