고혈압 환자에서 뇌졸중과 활동 동맥 경직도 및 혈압 일중변동의 연관성

• 영문명: Association of Stroke with Ambulatory Arterial Stiffness Index and Circardian Blood Pressure Variation in Hypertensive Patients
• 발행기관: 조선대학교 의학연구원
• 저자명: 정수철(Soo Chul Jung) 양서영(Seo Young Yang) 김도영(Do Young Kim) 김현목(Hyeon Mok Kim) 임현정(Hyun-jeong Im) 이창훈(C
• 간행물 정보: 『The Medical Journal of Chosun University』제38권 제4호, 166~171쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2013.12.31

영문 초록

The Ambulatory arterial stiffness index (AASI) and abnormal dipping patterns have been suggested as a risk factor for stroke. Recent studies have reported that AASI might be confounded by dipping patterns as a prognostic marker. We conducted a retrospective analysis of the data of 869 hypertensive patients for evaluation of the association of stroke with AASI and dipping patterns. AASI was higher in patients with stroke than in patients without stroke (0.47±0.16 vs. 0.41±0.17; p=0.083) and inversely related with nocturnal systolic BP reduction (r=–0.21; p<0.001). In multiple linear regression analysis, independent predictors of AASI were 24-hour pulse pressure (β= 0.447, p<0.001) and nocturnal dipping (β=–0.178, p<0.001). The odds ratio (OR) for stroke associated with AASI was 0.86 (95% confidence interval (CI), 0.29–2.5; p=0.777) after multivariate adjustment. Higher OR was observed for non-dippers, extreme-dippers, and reverse-dippers than for dippers (OR 1.57; 95% CI 1.02–2.4, p=0.04, OR 2.71; 95% CI 1.06–6.88, p=0.037, OR 2.56; 95% CI 1.56–4.2, p<0.001, respectively). The results of this study show that dipping pattern has a stronger association with stroke than AASI in patients with hypertension.

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키워드

Stroke Ambulatory blood pressure monitoring Arterial stiffness Dipping pattern