학술논문
Human umbilical cord blood mesenchymal stem cells engineered to overexpress growth factors accelerate outcomes in hair growth
이용수 27
- 영문명
- 발행기관
- 대한생리학회-대한약리학회
- 저자명
- Dong Ho Bak Mi Ji Choi Soon Re Kim Byung Chul Lee Jae Min Kim Eun Su Jeon Wonil Oh Ee Seok Lim Byung
- 간행물 정보
- 『The Korean Journal of Physiology & Pharmacology』제22권 제5호, 555~566쪽, 전체 12쪽
- 주제분류
- 의약학 > 의학일반
- 파일형태
- 발행일자
- 2018.09.30
4,240원
구매일시로부터 72시간 이내에 다운로드 가능합니다.
이 학술논문 정보는 (주)교보문고와 각 발행기관 사이에 저작물 이용 계약이 체결된 것으로, 교보문고를 통해 제공되고 있습니다.
국문 초록
영문 초록
Human umbilical cord blood mesenchymal stem cells (hUCB-MSCs) are used in tissue repair and regeneration; however, the mechanisms involved are not well understood. We investigated the hair growth-promoting effects of hUCB-MSCs
treatment to determine whether hUCB-MSCs enhance the promotion of hair growth. Furthermore, we attempted to identify the factors responsible for hair growth. The effects of hUCB-MSCs on hair growth were investigated in vivo, and hUCB-MSCs advanced anagen onset and hair follicle neogeneration. We found that hUCB-MSCs coculture
increased the viability and up-regulated hair induction-related proteins of human dermal papilla cells (hDPCs) in vitro. A growth factor antibody array revealed that secretory factors from hUCB-MSCs are related to hair growth. Insulin-like growth factor binding protein-1 (IGFBP-1) and vascular endothelial growth factor (VEGF) were increased in co-culture medium. Finally, we found that IGFBP-1, through the colocalization of an IGF-1 and IGFBP-1, had positive effects on cell viability; VEGF secretion; expression of alkaline phosphatase (ALP), CD133, and β-catenin; and formation of hDPCs 3D spheroids. Taken together, these data suggest that hUCB-MSCs promote hair growth via a paracrine mechanism.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
해당간행물 수록 논문
- Tetramethylpyrazine reverses anxiety-like behaviors in a rat model of post-traumatic stress disorder
- Antipruritic effect of curcumin on histamine-induced itching in mice
- The combination of canagliflozin and omega-3 fatty acid ameliorates insulin resistance and cardiac biomarkers via modulation of inflammatory cytokines in type 2 diabetic rats
- The change of signaling pathway on the electrical stimulated contraction in streptozotocin-induced bladder dysfunction of rats
- Botulinum toxin type A enhances the inhibitory spontaneous postsynaptic currents on the substantia gelatinosa neurons of the subnucleus caudalis in immature mice
- Inhibition of voltage-dependent K+ current in rabbit coronary arterial smooth muscle cells by the class Ic antiarrhythmic drug propafenone
- Human umbilical cord blood mesenchymal stem cells engineered to overexpress growth factors accelerate outcomes in hair growth
- Lysophosphatidic acid enhances breast cancer cells-mediated osteoclastogenesis
- Carbon monoxide releasing molecule-2 protects mice against acute kidney injury through inhibition of ER stress
- Influence of rutin on the effects of neonatal cigarette smoke exposure-induced exacerbated MMP-9 expression, Th17 cytokines and NF-kB/iNOS-mediated inflammatory responses in asthmatic mice model
- Tricyclic antidepressant amitriptyline inhibits 5-hydroxytryptamine 3 receptor currents in NCB-20 cells
- Conditioning-induced cardioprotection
- Extracellular acidity enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis via DR5 in gastric cancer cells
참고문헌
관련논문
의약학 > 의학일반분야 BEST
- 교육전담간호사가 주도하는 임상현장교육 프로그램이 신규 간호사의 간호업무성과와 교육 만족도에 미치는 효과
- 일반인을 위한 해부학 만화
- 간호대학생의 MBTI 성격유형별 의사소통능력, 자아존중감, 학업성취도의 관계
의약학 > 의학일반분야 NEW
- 안구내용적출 시 자가통증조절장치를 이용한 선제적 전신 진통제의 효과
- 빅데이터를 이용한 COVID-19 백신 접종 후 발생한 안과적 이상사례에 대한 고찰
- 만성 중심장액맥락망막병증에서 국소레이저광응고술과 유리체 내 베바시주맙 주입술의 효과 비교
최근 이용한 논문
교보eBook 첫 방문을 환영 합니다!
신규가입 혜택 지급이 완료 되었습니다.
바로 사용 가능한 교보e캐시 1,000원 (유효기간 7일)
지금 바로 교보eBook의 다양한 콘텐츠를 이용해 보세요!