학술논문
Antipruritic effect of curcumin on histamine-induced itching in mice
이용수 12
- 영문명
- 발행기관
- 대한생리학회-대한약리학회
- 저자명
- Han Kyu Lee Seok Bum Park Su-youne Chang Sung Jun Jung
- 간행물 정보
- 『The Korean Journal of Physiology & Pharmacology』제22권 제5호, 547~554쪽, 전체 8쪽
- 주제분류
- 의약학 > 의학일반
- 파일형태
- 발행일자
- 2018.09.30
4,000원
구매일시로부터 72시간 이내에 다운로드 가능합니다.
이 학술논문 정보는 (주)교보문고와 각 발행기관 사이에 저작물 이용 계약이 체결된 것으로, 교보문고를 통해 제공되고 있습니다.
국문 초록
영문 초록
Itching is a common clinical symptom of skin disease that significantly affects a patient’s quality of life. Transient receptor potential vanilloid 1 (TRPV1) receptors of keratinocytes and peripheral nerve fibers in skin are involved in the regulation of itching as well as pain. In this study, we investigated whether curcumin, which acts on TRPV1 receptors, affects histamine-induced itching in mice, using behavioral tests and electrophysiological approaches. We found that histamine-induced itching was blocked by topical application of curcumin in a concentration-dependent manner. In ex-vivo recordings, histamine-induced discharges of peripheral nerves were reduced by the application of curcumin, indicating that curcumin acts directly on peripheral nerves. Additionally, curcumin blocked the histamine-induced inward current via activation of TRPV1 (curcumin IC50=523 nM). However, it did not alter chloroquine-induced itching behavior in mice, which is associated with transient receptor potential ankyrin 1 (TRPA1). Taken together, our results suggest that histamine-induced itching can be blocked by topical application of curcumin through the inhibitory action of curcumin on TRPV1 receptors in peripheral nerves.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
해당간행물 수록 논문
- Tetramethylpyrazine reverses anxiety-like behaviors in a rat model of post-traumatic stress disorder
- Antipruritic effect of curcumin on histamine-induced itching in mice
- The combination of canagliflozin and omega-3 fatty acid ameliorates insulin resistance and cardiac biomarkers via modulation of inflammatory cytokines in type 2 diabetic rats
- The change of signaling pathway on the electrical stimulated contraction in streptozotocin-induced bladder dysfunction of rats
- Botulinum toxin type A enhances the inhibitory spontaneous postsynaptic currents on the substantia gelatinosa neurons of the subnucleus caudalis in immature mice
- Inhibition of voltage-dependent K+ current in rabbit coronary arterial smooth muscle cells by the class Ic antiarrhythmic drug propafenone
- Human umbilical cord blood mesenchymal stem cells engineered to overexpress growth factors accelerate outcomes in hair growth
- Lysophosphatidic acid enhances breast cancer cells-mediated osteoclastogenesis
- Carbon monoxide releasing molecule-2 protects mice against acute kidney injury through inhibition of ER stress
- Influence of rutin on the effects of neonatal cigarette smoke exposure-induced exacerbated MMP-9 expression, Th17 cytokines and NF-kB/iNOS-mediated inflammatory responses in asthmatic mice model
- Tricyclic antidepressant amitriptyline inhibits 5-hydroxytryptamine 3 receptor currents in NCB-20 cells
- Conditioning-induced cardioprotection
- Extracellular acidity enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis via DR5 in gastric cancer cells
참고문헌
관련논문
의약학 > 의학일반분야 BEST
- 교육전담간호사가 주도하는 임상현장교육 프로그램이 신규 간호사의 간호업무성과와 교육 만족도에 미치는 효과
- 일반인을 위한 해부학 만화
- 간호대학생의 MBTI 성격유형별 의사소통능력, 자아존중감, 학업성취도의 관계
의약학 > 의학일반분야 NEW
- 안구내용적출 시 자가통증조절장치를 이용한 선제적 전신 진통제의 효과
- 빅데이터를 이용한 COVID-19 백신 접종 후 발생한 안과적 이상사례에 대한 고찰
- 만성 중심장액맥락망막병증에서 국소레이저광응고술과 유리체 내 베바시주맙 주입술의 효과 비교
최근 이용한 논문
교보eBook 첫 방문을 환영 합니다!
신규가입 혜택 지급이 완료 되었습니다.
바로 사용 가능한 교보e캐시 1,000원 (유효기간 7일)
지금 바로 교보eBook의 다양한 콘텐츠를 이용해 보세요!