Collagenase가 백서치아이동 후 복귀현상에 미치는 효과에 관한 조직화학적 연구

• 영문명: AN HISTOCHEMICAL STUDY ON THE EFFECTS OF COLLAGENASE DURING THE RELAPSE PERIOD FOLLOWING RAT S TOOTH MOVEMENT
• 발행기관: 대한치과교정학회
• 저자명: 황현수(Hyun-Soo Whang) 유영규(Young-Kyu Ru)
• 간행물 정보: 『The Korean Journal of Orthodontics』제14권 제1호, 173~182쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1984.06.30

영문 초록

The author has observed the effects of collagenase on the relapse phenomenon and the histochemical changes during the relapse period. 50 rats were used. : 3rats as a normal group, 15rats as control groups, and 32rats as experimental groups. Rat´s teeth were moved for 10days with helical spring applied, followed by injection of collagenase in Hank´s sol. to the experimental groups and the Hank´s sol. to the control group in the interdental gingiva on the 10th day, and the spring was removed on the 11th day. After injection, the experimental animals were sacrificed on the 11th, 13th, 15th, 17th, 20th, and 24th day and perpared histochemically for the Hematoylin-Eosin, Van-Gieson, and Methyl Green-pyronin staining. The results are as follows: 1. Group I (11th day): In the control group the supracrestal fibers were stretched and the metabolic rate was high. Experimental group showed that supracrestal fibers were resor, bed, disarrayed, and the metabolic rate was low. 2. Group II (13th day): In the control group, the supracrestal fibers began to vhange from the vertical direction to tooth-axis to the parallel. Experimental group showed that supracrestal fibers were completely resorbed. 3. Group IV (17th day): The control group showed almost normal structure. Form this group the metabolic rates were low. Experimental group showed the most destructive pattern. 4. Group VI (24th day): Experimental group showed almost normal structure. It follows that experimental groups were relapsed less than the control groups, and collagenase was effective in the prebention of relapse after rat´s experimental tooth movement.