치과에서 사용되는 수종의 소염진통제가 치아이동에 미치는 영향에 관한 실험적 연구

• 영문명: EXPERIMENTAL STUDY OF THE EFFECTS OF NON-STEROIDAL ANTI-INFLAMMATORY AGENTS USED IN DENTAL CLINIC ON ORTHODONTIC TOOTH MOVEMENT IN RATS
• 발행기관: 대한치과교정학회
• 저자명: 김태원(Tae-Won Kim) 유영규(Young Kyu Ryu)
• 간행물 정보: 『The Korean Journal of Orthodontics』제22권 제3호, 579~587쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1992.09.30

영문 초록

Non-steroidal anti-inflammatory agents are used to relieve pain and to reduce swelling in dental clinics. This experiment was performed to study the effect of non-steroidal anti-inflammatory agents in Sprague-Dawley rats on orthodontic tooth movement. Thirty rats were used and divided six groups of five rats each. The first group, administered saline and no orthodontic force, served as a normal group. The second group, administered saline and applied experimental force, was control group. The other four groups were administered Aspirin, Pontal, Tyrenol and Indomethacin each, and applied experimental orthodontic force by 1/4 inch elastic, inserted into the interproximal space between maxillary first and second molar in rats. All experimental rats were sacrificed after three days, and the specimens were sectioned horizontally five times serially, and counted the number of osteoclasts appeared at the compressed surface of interradicular bone on first buccal root of first molar on light microscope. The obtained results were as follows: 1. The number of osteoclast on the compressed surface of the interradicular bone on first buccal root of the first molar in the four non-steroidal anti-inflammatory agents groups decreased in contrast to control group. 2. In non-steroidal anti-inflammatory agents group, the number of osteoclast in Indomethacin group was least among the all non-steroidal anti-inflammatory agents groups. From the above results, it was believed that the non-steroidal anti-inflammatory agents may have the inhibitory effect of tooth movement during orthodontic treatment.