Do Opioid Receptors Play a Role in Blood Pressure Regulation?

• 영문명: Do Opioid Receptors Play a Role in Blood Pressure Regulation?
• 발행기관: 대한약리학회
• 저자명: Rhee H.M. J.W. Holaday J.B. Long M.D. Gaumann T.L. Yaksh G.M. Tyce W.R. Dixon A.P. Chang J.A. Mastri
• 간행물 정보: 『대한약리학잡지』제24권 제2호, 153~164쪽, 전체 12쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1988.12.31

영문 초록

The potential role of endogenous opioid peptides (EOPS) in cardiovascular regulation has only recently been entertained. EOPS have been localized in brain, spinal cord, autonomic ganglia, particularly the adrenal gland, and many other peripheral tissues. There are at least five major types of opioid receptors; namely μ, δ, k, σ, and ε and Experimental evidence indicates that cardiovascular actions of the peptide are mediated primarily by μ, δ and k receptors, and that these receptor types may be allosterically coupled. In anesthetized rabbits met-enkephalin decreased blood pressure and heart rate, which closely paralleled a reduction in sympathetic discharge. Naloxone, but not naloxone methobromide, antagonized these effects, which suggests a central site of action of met-enkephalin. A number of autonomic agents, particularly adrenergic α-and, β-agonists and antagonists modify the cardiovascular actions of met-enkephalin. Experiments in reserpine-treated and adrenalectomized rats provide no evidence of sympathetic nervous system involvement in the pressor responses to intravenous injection of opioid peptides, but rather suggest a direct peripheral action. Finally, activation of a beta-endorphinergic pathway projecting from the arcuate nucleus to the nucleus tractos solitarii in rats can cause naloxone reversible hypotension and bradycardia. There is evidence to implicate this pathway in antihypertensive drug action and in the modulation of baroreflex activity.

키워드

Opioid Peptide Opioid Receptor Cardiovascular Blood pressure Sympathetic System