토끼의 혈장내 Aldosterone 농도에 미치는 Aspirin과 Furosemide의 영향

• 영문명: Effects of Aspirin and Furosemide on Plasma Aldosterone Level in Rabbits
• 발행기관: 대한약리학회
• 저자명: 서영진(Y.J. Suh) 이권행(K.H. Lee) 김옥녀(O.N. Kim) 이상복(S.B. Lee) 조규철(K.C. Cho)
• 간행물 정보: 『대한약리학잡지』제20권 제2호, 1~6쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1984.12.31

영문 초록

It has been generally recognized that the secretion of aldosterone is mainly regulated by angiotensin II in animals and humans, however, potassium and ACTH are also proposed as other humoral factors involved in the aldosterone secretory process. Recently, stress, anesthesia, adrenergic stimulation, low sodium intake or water deprivation stimulate plasma renin activity, while high sodium intake and deoxycorticosteroid have been reported to cause suppression of renin activity in animals. It seems that overall response of aldosterone secretory mechanisms reflects complex interactions both intrarenal and extrarenal components. Furosemide has been widely used to investigate the control of renin secretion by the kidney, and the relationship between diuretics and the disposition of endogenous aldosterone were reported (Oh, 1984). The sequential with 10 min interval samples of plasma were collected following administration of furosemide(1 mg/kg), aspirin(10 mg/kg), respectively. And also similar experiment was performed in the propranolol (10 mg/kg) pretreated rabbits. The results were as follows : 1) The concentration of plasma aldosterone was average of 426.I ~ 485.5pg/ml in normal rabbits. Plasma concentrations of aldosterone rised significantly after injection of furosemide during 50 min, and the rise of plasma aldosterone was blocked by the propranolol pretreatment 2) Significant fall in the plasma level of aldosterone after injection of aspirin was noted. This result indicates that the increased secretion of aldosterone induced by furosemide administration is mediated through β-receptors, and the possible role of prostaglandin is substantiated.