고장수액의 위내 주입으로 인한 취외분비의 변동

• 영문명: Effects of Intragastric Hypertonic Solution on Pancreatic Exocrine Secretion
• 발행기관: 대한약리학회
• 저자명: 조태순(T.S. Cho) 김원준(W.J. Kim) 홍사석(S.S. Hong)
• 간행물 정보: 『대한약리학잡지』제13권 제1호, 29~33쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1977.06.30

영문 초록

Effects of 50% glucose solution on pancreatic exocrine function were studied in rat, rabbit and cat. The alterations during the resting state, the continuous intravenous infusion of secretin and the infusion of secretin with CCK-PZ were determined. 1) No change of pancreatic secretion in rat was observed by intragastric administration of the hypertonic glucose solution. 2) Intragastric administration of the hypertonic glucose solution in rabbit produced the inhibitory effect on pancreatic secretion during secretion infusion. 3) While secretin with CCK-PZ were infused continuously, intragastric administration of the hypertonic glucose solution revealed the marked inhibitory effect on pancrcreatic secretion in cat. Oral administration of the hypertonic glucose solution produced no significant inhibition in the resting gland but markedly depressed the pancreatic flow and enzyme concentration in the secretin or CCK-PZ stimulated gland. It is felt that the inhibitory response of exocrine pancreas induced by intragastric hytertonic glucose solution is resulted in interaction between secretory hormone and gastric mucosal factor possibly enteroglucagon.