생약진피(生藥陳皮)의 심혈관계(心血管系)에 대한 약리작용(藥理作用)

• 영문명: Pharmacological Actions of Extracts of Citrus unshiu Pericarpium on Cardiovascular System
• 발행기관: 대한약리학회
• 저자명: 이병학(Lee, Byung-Hak) 조태순(Cho, Tai-Soon) 이우주(Lee, Woo-Choo)
• 간행물 정보: 『대한약리학잡지』제10권 제2호, 31~38쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1974.12.31

영문 초록

Citrus unshiu Marc., a family of Rutaceae, has been used as antitussives, antiemetics, expectorants, spasmolytics, stomachics and digestants in oriental medicine. But there is few reports on the pharmacological effects of Citrus unshiu pericarpium. Present experiment was performed to observe the effects of the water extract of Citrus unshiu on isolated auricle and intestine in rabbits and blood pressure in rats and also to study on the active component on the cardiovascular system by means of thin layer chlomatography and spectrophotometer. 1. The water extract showed positive inotropic and positive chronotropic effect in the concentration of 1 X 10^-4g/ml, 5 X 10^-4g/ml, and 1 X 10^-3g/ml. 2. The motility of isolated rabbit intestine was significantly depressed by the water extract. 3. The blood pressure was markedly increased by the water extract. 4. The blood vessel of rabbit ear was constricted by perfusion of the ether extract. 5. The purified alkaloid of Citri pericarpium by ion exchange resin showed the same Rf value with l-synephrine on thin layer chromatography. 6. The purified alkaloid of Citri pericarpium by thin layer chromatography showed the same absorption curve with l-synephrine in the ultraviolet scanning.