신세뇨관기능(腎細尿管機能)에 미치는 Bradykinin의 영향(影響)

• 영문명: Influence of Bradykinin on the tubular function of the dog kidney
• 발행기관: 대한약리학회
• 저자명: 서병철(Sub, Byoung-Chul)
• 간행물 정보: 『대한약리학잡지』제2권 제1호, 5~12쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1966.05.31

영문 초록

In this study the influence of Bradykinin, a biogenic polypeptide, on the excretory function of the dog kidney was investigated, utilizing the clearance and stop-flow method. The results are summarized as follows; 1) Bradykinin administered intravenously elicited a marked antidiuresis. 2) When given into the renal artery, however, prompt increase of the urine flow, sodium excretion and free water clearance without significant change in the glomerular filtration rate ensued. 3) It was also effective during an osmotic diuresis with 10% Mannitol infusion, though the response was not so marked. 4) The stop-flow experiment showed that sodium reabsorption in the proximal tubules is inhibited by the infusion of bradykinin into the renal artery. It was thus concluded that the diuretic effect of bradykinin given intra-arterially results from the inhibition of sodium transport in the proximal tubules.