Lipidomic analysis of plasma lipids composition changes in septic mice

• 발행기관: 대한생리학회-대한약리학회
• 저자명: Won-Gyun Ahn Jun-Sub Jung Dong-Keun Song
• 간행물 정보: 『The Korean Journal of Physiology & Pharmacology』제22권 제4호, 399~408쪽, 전체 10쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2018.07.31

영문 초록

A lipidomic study on extensive plasma lipids in bacterial peritonitis (cecalligation and puncture, CLP)-induced sepsis in mice was done at 24 h post-CLP. The effects of administration of lysophosphatidylcholine (LPC) and lysophosphatidic acid(LPA), compounds known to have beneficial effects in CLP, on the sepsis-induced plasma lipid changes were also examined. Among the 147 plasma lipid species from 13 lipid subgroups (fatty acid [FA], LPA, LPC, lysophosphatidylethanolamine [LPE],phosphatidic acid [PA], phosphatidylcholine [PC], phosphatidylethanolamine [PE],phosphatidylinositol [PI], monoacylglyceride [MG], diacylglyceride [DG], triacylglyceride[TG], sphingomyelin [SM], and ceramide [Cer]) analyzed in this study, 40 and 70 species were increased, and decreased, respectively, in the CLP mice. Treatments with LPC and LPA affected 14 species from 7 subgroups, and 25 species from 9 subgroups, respectively. These results could contribute to finding the much needed reliable biomarkers of sepsis.

목차

INTRODUCTION

METHODS

RESULTS

DISCUSSION

ACKNOWLEDGEMENTS

CONFLICTS OF INTEREST

REFERENCES

키워드

Lipidomics Mice Plasma Sepsis