Role of peripheral vestibular receptors in the control of blood pressure following hypotension

• 발행기관: 대한생리학회-대한약리학회
• 저자명: Guang-Shi Jin Xiang-Lan Li Yuan-Zhe Jin Min Sun Kim Byung Rim Park
• 간행물 정보: 『The Korean Journal of Physiology & Pharmacology』제22권 제4호, 363~368쪽, 전체 6쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2018.07.31

영문 초록

Hypotension is one of the potential causes of dizziness. In this review, we summarize the studies published in recent years about the electrophysiological and pharmacological mechanisms of hypotension-induced dizziness and the role of the vestibular system in the control of blood pressure in response to hypotension. It is postulated that ischemic excitation of the peripheral vestibular hair cells as a result of a reduction in blood flow to the inner ear following hypotension leads to excitation of the central vestibular nuclei, which in turn may produce dizziness after hypotension. In addition, excitation of the vestibular nuclei following hypotension elicits the vestibulosympathetic reflex, and the reflex then regulates blood pressure by a dualcontrol(neurogenic and humoral control) mechanism. In fact, recent studies have shown that peripheral vestibular receptors play a role in the control of blood pressure through neural reflex pathways. This review illustrates the dual-control mechanism of peripheral vestibular receptors in the regulation of blood pressure following hypotension.

목차

INTRODUCTION

RESPONSE OF PERIPHERAL VESTIBULAR RECEPTORS FOLLOWING HYPOTENSION

SIGNALING PATHWAY IN THE VESTIBULAR NUCLEI FOLLOWING HYPOTENSION

ROLE OF THE SOLITARY TRACT NUCLEUS(STN) IN HYPOTENSION

ROLE OF THE RVLM IN HYPOTENSION

ROLE OF THE IMC IN HYPOTENSION

ROLE OF THE ADRENAL MEDULLA IN THE VSR

ACKNOWLEDGEMENTS

CONFLICTS OF INTEREST

REFERENCES

키워드

Dizziness Epinephrine Glutamate Hypotension Vestibulosympathetic reflex