Effects of Uric Acid on the Alterations of White Matter Connectivity in Patients with Major Depression

• 발행기관: 대한신경정신의학회
• 저자명: Hoyoung Sohn Min-Soo Kwon Sun-Woo Lee Jongsoo Oh Min-Kyoung Kim Sang-Hyuk Lee Kang Soo Lee Borah Kim
• 간행물 정보: 『Psychiatry Investigation』제15권 제6호, 593~601쪽, 전체 9쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2018.06.30

영문 초록

Objective Uric acid is a non-enzymatic antioxidant associated with depression. Despite its known protective role in other brain disorders, little is known about its influence on the structural characteristics of brains of patients with major depressive disorder (MDD). This study explored the association between uric acid and characteristics of white matter (WM) in patients with MDD. Methods A total of 32 patients with MDD and 23 healthy controls (HCs) were examined. All participants were scored based on the Beck Depression Inventory and Beck Anxiety Inventory at baseline. All patients were also rated with the Hamilton Depression Rating Scale. We collected blood samples from all participants immediately after their enrollment and before the initiation of antidepressants in case of patients. Tract-based spatial statistics were used for all imaging analyses. Results Lower fractional anisotropy (FA) and higher radial diffusivity (RD) values were found in the MDD group than in the HC group. Voxelwise correlation analysis revealed that the serum uric acid levels positively correlated with the FA and negatively with the RD in WM regions that previously showed significant group differences in the MDD group. The correlated areas were located in the left anterior corona radiata, left frontal lobe WM, and left anterior cingulate cortex WM. Conclusion The present study suggests a significant association between altered WM connectivity and serum uric acid levels in patients with MDD, possibly through demyelination.

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키워드

Depressive disorder Uric acid Oxidative stress Antioxidants White matter Neuroimaging