Cardamonin inhibits agonist-induced vascular contractility via Rho-kinase and MEK inhibition

• 영문명: Cardamonin inhibits agonist-induced vascular contractility via Rho-kinase and MEK inhibition
• 발행기관: 대한생리학회-대한약리학회
• 저자명: Hyun Dong Je Ji Hoon Jeong
• 간행물 정보: 『The Korean Journal of Physiology & Pharmacology』제20권 제1호, 69~74쪽, 전체 6쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2016.01.01

영문 초록

The present study was undertaken to investigate the influence of cardamonin on vascular smooth muscle contractility and to determine the mechanism(s) involved. Denuded aortic rings from male rats were used and isometric contractions were recorded and combined with molecular experiments. Cardamonin significantly relaxed fluoride-, phenylephrine-, and phorbol ester-induced vascular contractions, suggesting that it has an anti-hypertensive effect on agonist-induced vascular contraction regardless of endothelial nitric oxide synthesis. Furthermore, cardamonin significantly inhibited the fluoride-induced increase in pMYPT1 level and phenylephrine-induced increase in pERK1/2 level, suggesting inhibition of Rho-kinase and MEK activity and subsequent phosphorylation of MYPT1 and ERK1/2. This study provides evidence that the relaxing effect of cardamonin on agonist-induced vascular contraction regardless of endothelial function involves inhibition of Rho-kinase and MEK activity.

키워드

Cardamonin ERK1/2 Fluoride MYPT1 Rho-kinase