Toxicokinetics of paraquat in Korean patients with acute poisoning

• 영문명: Toxicokinetics of paraquat in Korean patients with acute poisoning
• 발행기관: 대한생리학회-대한약리학회
• 저자명: Hak-Jae Kim Hyung-Ki Kim Hwayoung Lee Jun-Seok Bae Jun-Tack Kown Hyo-Wook Gil Sae-Yong Hong
• 간행물 정보: 『The Korean Journal of Physiology & Pharmacology』제20권 제1호, 35~39쪽, 전체 5쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2016.01.01

영문 초록

To conduct a kinetic study of paraquat (PQ), we investigated 9 patients with acute PQ intoxication. All of them ingested more than 20 ml of undiluted PQ herbicide to commit suicide and arrived at our hospital early, not later than 7 h after PQ ingestion. The urine dithionite test for PQ in all of the nine patients was strongly positive at emergency room. Blood samples were obtained every 30 min for the first 2~3 h and then every 1 or 2 h, as long as the clinical progression was stable among the patients for 30 h after PQ ingestion. The area under the plasma concentrationtime curve (AUC_inf), which was extrapolated to infinity, was calculated using the trapezoidal rule. Toxicokinetic parameters, such as the terminal elimination half-life, apparent oral clearance, and apparent volume of distribution (V_d/F) were calculated. The maximum PQ concentration (C_max) and the time to reach maximum PQ concentration (T_max) were also obtained. Plasma PQ concentrations in nine patients were well described by a bi-exponential curve with a mean terminal elimination half-life of 13.1±6.8 h. C_max and AUC_inf were 20.8±25.7 mg/l and 172.5±160.3 h·mg/ l, respectively. Apparent volume of distribution and apparent oral clearance were 50.9±61.3 l/kg and 173.4±111.2 l/h, respectively. There were a significant correlation (r =0.84; p<0.05) between the PQ amount ingested and C_max. AUC_inf also showed a significant correlation (r =0.83; p<0.05) with the PQ amount ingested. These correlations provide evidence that PQ has dose-linear toxicokinetic characteristics.

키워드

Paraquat Poisoning Toxicokinetics