Diminished Vascular Guanylyl Cyclase Activity in Deoxycorticos- terone Acetate-Salt Hypertension

• 영문명: Diminished Vascular Guanylyl Cyclase Activity in Deoxycorticos- terone Acetate-Salt Hypertension
• 발행기관: 대한생리학회-대한약리학회
• 저자명: JongUn Lee Jung Hee Hong
• 간행물 정보: 『The Korean Journal of Physiology & Pharmacology』제4권 제5호, 379~383쪽, 전체 5쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2000.01.01

영문 초록

Pathophysiological implications of the vascular nitric oxide (NO)/cGMP pathway in hypertension were investigated. Sprague-Dawley rats were made deoxycorticosterone acetate (DOCA)-salt hypertensive for six weeks. The protein expression of endothelial constitutive NO synthase (ecNOS) and the tissue content of NO were determined in the thoracic aorta. The protein expression and catalytic activity of soluble guanylyl cyclase (GC) were also determined. Systolic blood pressure measured on the day of experiment was significantly higher in the experimental group than in the control. The hypertension was associated with decreases in the vascular tissue content of NO metabolites, concomitantly with the expression of ecNOS proteins. The protein expression of GC was not affected, while its catalytic activity was significantly decreased in hypertension. These results indicate that the high blood pressure is associated with a decreased activity of vascular NO/cGMP pathway in DOCA-salt hypertension.

키워드

Nitric oxide synthase Guanylyl cyclase Deoxycorticosterone acetate-salt hypertension