제1형 양극성 장애 환자에서 조증 삽화의 증상 심각도, 혈청 요산 농도 및 정량화 뇌파 소견의 관계

• 영문명: The Correlation between Clinical Symptoms, Serum Uric Acid Level and EEG in Patient with Bipolar I Disorder
• 발행기관: 대한신경정신의학회
• 저자명: 김영인 김선미 홍지선 송진욱 한덕현 민경준 이영식
• 간행물 정보: 『신경정신의학』제55권 제1호, 25~32쪽, 전체 8쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2016.02.29

영문 초록

Objectives ZZHigh uric acid level is related to increased locomotor activities and refractory mood swings. The urpose of this study is to examine the correlation between clinical symptoms of mania, serum uric acid level, and uantitative electroencephalography (QEEG) findings. Methods ZZTwenty-four patients with bipolar disorder and 24 healthy control subjects agreed to participate in the tudy. When they were hospitalized, the degree of clinical symptoms, uric acid level in blood, and brain QEEG were easured. Results ZZThe bipolar disorder group showed higher scores on the Young Mania Rating Scale (YMRS ; z=6.02, p<0.05). Patients in their manic episodes showed higher plasma uric acid levels (4.9±1.3 mg/dL) than healthy control ubjects (4.2±0.9 mg/dL ; z=2.14, p<0.05). Uric acid levels showed correlation with severity of manic symptoms as ssessed using the YMRS in all participants (ρ=0.28, p<0.05). The bipolar disorder group showed decreased relative delta and alpha activity in the fronto-temporo-occipital region compared to the control group (p<0.05). Relative beta in Fp1 (frontopolar), Cz (central mid-line), and Pz (parietal mid-line) and relative gamma in Fp1 were increased in the bipolar disorder group, relative to the control group (p<0.05). The relative beta (ρ=0.47, p<0.05) and gamma (ρ=0.41, p<0.05) in Fp1 electrodes showed positive correlation with the YMRS scores. Conclusion ZZAdenosinergic transmission dysfunction may lead to occurrence of manic symptoms, considering that a key role of central nervous system adenosinergic receptors is to inhibit the release of various neurotransmitters and limit neuronal excitability. In addition, QEEG appeared to indicate excitatory neuro-modulation in manic patients.

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키워드

Uric acid Bipolar disorder Mania Quantitative electroencephalography