통각유발물질에 의한 척수후각세포의 반응에 미치는 Clonidine의 영향

• 영문명: Effect of Clonidine on the Changes in Dorsal Horn Cell Activity Induced by Chemical Algogenics
• 발행기관: 대한생리학회
• 저자명: 이광훈(Lee, Kwang-Hoon) 김진혁(Kim, Jin-Hyuk) 신홍기(Shin, Hong-Kee) 김기순(Kim, Kee-Soon)
• 간행물 정보: 『대한생리학회지』제22권 제2호, 245~258쪽, 전체 14쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 1988.12.31

영문 초록

The present study was undertaken to investigate the effect of clonidine on the response of the dorsal horn cells to intra-arterially administered bradykinin (BK:40μg) and K⁺(4mg) in spinal cats and cats with intact spinal cord. The change in the activities of low threshold (LT), high threshold (HT) and wide dynamic range (WDR) cells induced by BK and K⁺ were determined before and after treatment of animals with clonidine. Also studied was mechanism of inhibitory action of clonidine on the responses of dorsal horn cells to the chemical algogenics. Number of WDR cell responded to intra-arterially administered BK and K⁺ was greater in spinal animals than in cats with intact spinal cord. Following administration of BK or K⁺ no change was observed in the activity of LT cell whereas activity of HT cell increased invariably. The increased response of HT cell to BK and K⁺ was markedly suppressed by clonidine. On the other hand, such inhibitory actions of clonidine were almost completely blocked by yohimbine. The majority of WDR cells were activated by K⁺ while response of WDR cells to BK was diverse (excitatory, inhibitory or mixed). These results indicate that clonidine inhibits responses of the dorsal horn cells not only to thermal or mechanical stimulations but also to chemical algogenics, and that the inhibitory action of clonidine is generally mediated through excitation of α₂-adrenoreceptors.

키워드

Drosal horn cells Bradykinin K⁺ Spinal animals Yohimbine Clonidine