Glycine에 의한 가토심방근 및 동방결절세포의 활동전압의 변동

• 영문명: Effect of Glycine on the Action Potential of the Atrial Muscle and Sinus Node Cells of the Rabbit Heart
• 발행기관: 대한생리학회
• 저자명: 최경훈(Choe, Kyung-Hoon) 김진혁(Kim, Jin-Hyuk) 고상돈(Koh, Sang-Don) 신흥기(Shin, Hong-Kee) 김기순(Kim, Kee-Soon)
• 간행물 정보: 『대한생리학회지』제22권 제2호, 219~230쪽, 전체 12쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 1988.12.31

영문 초록

The effect of glycine, structurally the most simple amino acid was investigated on the electrophysiological characteristics of the isolated superfused atrial muscle and sinus node cells of the rabbit heart. Superfusion of the sinus node cell with glycine solution (3, 5 and 8 mM) produced concentration-dependent increments of OS (overshoot potential) and MDP (maximum diastolic potential). Generally action potential amplitude increased as a result of greater increment of OS than that of MDP. The changes in action potential of the sinus node cell peaked in 7 ~ 10 minutes after onset of superfusioin. On the contrary to the response to intravenously administered glycine, the rate of spontaneous firing of sinus node cell was invariably increased following superfusion with glycine. Action potential duration manifested as APD₆₀ (time to 60% repolarization) was significantly shortened by glycine. And the electrophysiological effects of glycine on the atrial muscle cell were similar to that on the sinus node cells. The results of present study suggest that glycine can exert direct effects on the atrial muscle and sinus node cells of the rabbit heart.

키워드

Glycine Atrial muscle Sinus node