Taurine 및 ß-alanine이 고양이 척수후각세포의 Activity에 미치는 효과

• 영문명: Effects of Taurine and ß-alanine on the Responses of Dorsal Horn Cell to Various Stimuli in Cats
• 발행기관: 대한생리학회
• 저자명: 고영익(Koh, Young-Ik) 강석한(Kang, Sok-Han) 김진혁(Kim, Jin-Hyuk) 신홍기(Shin, Hong-Kee) 김기순(Kim, Kee-Soon)
• 간행물 정보: 『대한생리학회지』제24권 제1호, 171~180쪽, 전체 10쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 1990.06.30

영문 초록

In 19 cats anesthetized with α-chloralose effects of taurine and β-alanine on the responses of wide dynamic range (WDR) cells to mechanical, chemical and thermal stimuli were investigated in the lumbar spinal cord of the cat. Also studied was an interaction of strychnine with taurine in affecting the activities of WDR cells. Following intravenous administration of taurine, the responses of WDR cells to all types of mechanical stimuli were markedly enhanced, demonstrating that the response to pressure was most sensitive to taurine action. When the receptive field was exposed to thermal stimuli (50℃) for 20 sec. taurine increased activity of WDR cell to 169.5% of the control value. The K⁺-induced activation of WDR cells was invariably suppressed after taurine administration. Intravenously administered strychnine remarkably reduced the enhanced response of WDR cell to natural stimuli resulting from intravenous administration of taurine. Also β-alanine markedly activated the response of spinal dorsal horn cell to natural mechanical stimuli. These findings suggest that neutral amino acid and its derivative such as β-alanine and taurine can enhance the response of WDR cells to different stimuli in cats.

키워드

Taurine β-alanine Dorsal horn cell activity Strychnine