Three Cases of Reversible Agranulocytosis after Treatment with Lamotrigine

• 발행기관: 대한신경정신의학회
• 저자명: YongMin Ahn Kunjong Kim YongSik Kim
• 간행물 정보: 『Psychiatry Investigation』제5권 제2호, 121~123쪽, 전체 3쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2008.06.30

영문 초록

Several psychotropic drugs, including clozapine, are known to cause agranulocytosis and this may lead to a fatal condition. Lamotrigine is an anticonvulsant that the Food and Drug Administration (FDA) has approved for the depression of bipolar disorder. A few cases of lamotrigine-induced agranulocytosis have been previously reported on, but the pathophysiology and clinical manifestations are not yet known. This case series reports on 3 patients with different medical conditions who experienced agranulocytosis during treatment with lamotrigine. In these cases, the agranulocytosis occurred a few weeks after initiation of lamotrigine and it rapidly disappeared after discontinuation. We also discuss several characteristics of lamotrigine-induced agranulocytosis.

목차

INTRODUCTION

CASE

DISCUSSION

REFERENCES

키워드

Lamotrigine Agranulocytosis Bipolar disorder