Prevalence of Alzheimer’s Dementia and Its Risk Factors in Community-Dwelling Elderly Koreans

• 발행기관: 대한신경정신의학회
• 저자명: SeokJu Choi SungSoo Jung YoungSun You BaeSeob Shin JiEun Kim SungWook Yoon DongWook Jeon JunHyung Ba
• 간행물 정보: 『Psychiatry Investigation』제5권 제2호, 78~85쪽, 전체 8쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2008.06.30

영문 초록

Objective-We estimated the prevalence of Alzheimer’s dementia (AD) and mild cognitive impairment (MCI) and their risk factors in an urban community setting, focusing especially on metabolic syndrome. Methods-A two-phase investigation based on a door-to-door survey was performed. In Phase I, we administered the Korean version of the Mini-Mental State Examination (MMSEKC) of the Consortium to Establish a Registry for Alzheimer’s disease (CERAD-K). Assessment Packet and the Korean version of the Geriatric Depression Scales (GDS-K) to all 706 participants aged 65 years or older. In Phase II of the study, 175 persons underwent physical and neurological examinations according to the protocol of the CERAD-K clinical assessment battery [CERAD-K (C)] and the neuropsychological assessment battery [CERAD-K(N)]. We also examined the association between cognitive decline and metabolic syndrome. AD and MCI were defined using the DSM-IV-TR criteria and the Clinical Dementia Rating (CDR) scales. Results-The mean age (±SD) of the subjects was 74.3±16.7 years and the ratio of males to females was 53.2 to 46.8. The prevalence of Alzheimer’s dementia was 9.0%, while that of MCI was 32.9%. Old age and lower educational level had significant associations with cognitive decline in the elderly, but gender, years of alcohol intake or smoking, and metabolic syndrome were not associated with AD or MCI. Conclusion-In this study, metabolic syndrome was not associated with Alzheimer’s AD or MCI. Information regarding an association between Alzheimer’s dementia and metabolic syndrome in this study will be helpful in formulating future public health policy and prevention strategies in Korea.

목차

INTRODUCTION

METHODS

RESULTS

DISCUSSION

REFERENCES

키워드

Alzheimer’s dementia Mild cognitive impairment Prevalence Risk factor Metabolic syndrome