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학술논문

Imaging Improves Diagnosis of Dementia with Lewy Bodies

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영문명
발행기관
대한신경정신의학회
저자명
Masaru Tateno Seiju Kobayashi Toshikazu Saito
간행물 정보
『Psychiatry Investigation』제6권 제4호, 233~240쪽, 전체 8쪽
주제분류
의약학 > 정신과학
파일형태
PDF
발행일자
2009.12.31
4,000

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국문 초록

영문 초록

Dementia with Lewy bodies (DLB) is the second most common cause of degenerative dementia after Alzheimer’s disease (AD), and is clinically characterized by the progressive cognitive decline with fluctuations in cognition and alertness, recurrent visual hallucinations and Parkinsonism. Once these characteristic symptoms of DLB emerge, discriminating it from AD is relatively easy. However, in the early disease stages, the clinical symptoms of various types of dementias largely overlap and it is difficult to distinguish DLB from other neurodegenerative dementias based on clinical manifestations alone. To increase the accuracy of antemortem diagnosis of DLB, the latest diagnostic criteria incorporate findings from 123I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy, or from neuroimaging such as computed tomography (CT), magnetic resonance imaging (MRI), single photon emission computed tomography (SPECT), and positron emission tomography (PET). In the present guidelines, decreased dopamine transporter uptake revealed by SPECT or PET receives the greatest importance among various neuroimaging findings and is listed as one of the suggestive features. Supportive features that commonly present but are not proven to have diagnostic specificity include relatively-preserved medial-temporal-lobe structures, occipital hypoperfusion, and abnormal MIBG myocardial scintigraphy. In this paper, we review the major findings on various neuroimaging modalities and discuss the clinical usefulness of them for the diagnosis of DLB. Although there is not enough evidence to reach the conclusion, considering the accessibility in clinical practice, in our personal views, we recommend the use of brain-perfusion SPECT and MIBG myocardial scintigraphy to improve the diagnosis of DLB.

목차

Historical Background of Dementia with Lewy Bodies
Neuroimaging Studies in Dementia with Lewy Bodies
Conclusion
Acknowledgments
Regerences

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APA

Masaru Tateno,Seiju Kobayashi,Toshikazu Saito. (2009).Imaging Improves Diagnosis of Dementia with Lewy Bodies. Psychiatry Investigation, 6 (4), 233-240

MLA

Masaru Tateno,Seiju Kobayashi,Toshikazu Saito. "Imaging Improves Diagnosis of Dementia with Lewy Bodies." Psychiatry Investigation, 6.4(2009): 233-240

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