CDH13 and HCRTR2 May Be Associated with Hypersomnia Symptom of Bipolar Depression: A Genome-Wide Functional Enrichment Pathway Analysis

• 발행기관: 대한신경정신의학회
• 저자명: ChulHyun Cho HeonJeong Lee HyunGoo Woo JiHye Choi Tiffany A. Greenwood John R. Kelsoe
• 간행물 정보: 『Psychiatry Investigation』제12권 제3호, 402~407쪽, 전체 6쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2015.07.31

영문 초록

Although bipolar disorder is highly heritable, the identification of specific genetic variations is limited because of the complex traits underlying the disorder. We performed a genome-wide association study of bipolar disorder using a subphenotype that shows hypersomnia symptom during a major depressive episode. We investigated a total of 2,191 cases, 1,434 controls, and 703,012 single nucleotide polymorphisms (SNPs) in the merged samples obtained from the Translational Genomics Institute and the Genetic Association Information Network. The gene emerging as the most significant by statistical analysis was rs1553441 (odds ratio=0.4093; p=1.20×10-5; Permuted p=6.0×10-6). However, the 5×10-8 threshold for statistical significance required in a genome-wide association study was not achieved. The functional enrichment pathway analysis showed significant enrichments in the adhesion, development-related, synaptic transmission-related, and cell recognition-related pathways. For further evaluation, each gene of the enriched pathways was reviewed and matched with genes that were suggested to be associated with psychiatric disorders by previous genetic studies. We found that the cadherin 13 and hypocretin (orexin) receptor 2 genes may be involved in the hypersomnia symptom during a major depressive episode of bipolar disorder.

목차

INTRODUCTION

METHODS

RESULTS

DISCUSSION

SUPPLEMENTARY MATERIALS

ACKNOWLEDGEMENTS

REFERENCES

키워드

Genome-wide association study Bipolar disorder Hypersomnia Functional enrichment pathway analysis Bipolar depression