학술논문
Stem Cell Therapy: A Prospective Treatment for Alzheimer’s Disease
이용수 3
- 영문명
- 발행기관
- 대한신경정신의학회
- 저자명
- JiHan Lee IlHoan Oh HyunKook Lim
- 간행물 정보
- 『Psychiatry Investigation』제13권 제6호, 583~589쪽, 전체 7쪽
- 주제분류
- 의약학 > 정신과학
- 파일형태
- 발행일자
- 2016.11.30
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국문 초록
영문 초록
Alzheimer’s disease (AD) without cure remains as a serious health issue in the modern society. The major neuropathological alterations in AD are characterized by chronic neuroinflammation and neuronal loss due to neurofibrillary tangles (NFTs) of abnormally hyperphosphorylated tau, plaques of β-amyloid (Aβ) and various metabolic dysfunctions. Due to the multifaceted nature of AD pathology and our limited understanding on its etiology, AD is difficult to be treated with currently available pharmaceuticals. This unmet need, however, could be met with stem cell technology that can be engineered to replace neuronal loss in AD patients. Although stem cell therapy for AD is only in its development stages, it has vast potential uses ranging from replacement therapy to disease modelling and drug development. Current progress with stem cells in animal model studies offers promising results for the new prospective treatment for AD. This review will discuss the characteristics of AD, current progress in stem cell therapy and remaining challenges and promises in its development.
목차
INTRODUCTION
AD PATHOGENESIS AND CURRENT TREATMENTS
STEM CELL THERAPY FOR AD
CONCLUDING REMARKS
ACKNOWLEDGEMENTS
REFERENCES
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