학술논문
Differential Histone Acetylation in Sub-Regions of Bed Nucleus of the Stria Terminalis Underlies Fear Consolidation and Extinction
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- 영문명
- 발행기관
- 대한신경정신의학회
- 저자명
- Vandana Ranjan Sanjay Singh Sarfraj Ahmad Siddiqui Sukanya Tripathi Mohd Yahiya Khan Anand Prakash
- 간행물 정보
- 『Psychiatry Investigation』제14권 제3호, 350~359쪽, 전체 10쪽
- 주제분류
- 의약학 > 정신과학
- 파일형태
- 발행일자
- 2017.05.31
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국문 초록
영문 초록
Objective-The hallmark of anxiety disorders is excessive fear. Previous studies have suggested that selective neural projections from Basal nucleus of stria terminalis (BNST) to amygdala and vice-versa precisely control the fear learning process. However the exact mechanism how the BNST controls fear consolidation and its extinction is largely unknown. In the present study we observed the changes in the BNST sub-regions following fear conditioning and its extinction.
Methods-The change in the number of positive neurons was determined by immunohistochemistry for Acetyl H3 (Histone 3), Acetyl H4 (Histone 4), cAMP response element binding Protein (CBP) and c-fos in three sub-regions of the BNST namely the anterio-lateral BNST (STLP) and anterio-medial BNST (STMA), and lateral-ventral BNST (STLV) of rats subjected to auditory fear conditioning and extinction.
Results-We found significant increase in the number of CBP, acetyl H3 and acetyl H4 positive neurons in the STMA and STLV but not in the STLP after fear conditioning. However, following fear extinction the number of CBP, acetyl H3 and acetyl H4 positive neurons increased significantly in the STLP but not in the STMA and STLV. Similar changes were observed in the number of c-fos positive neurons after fear consolidation and extinction.
Conclusion-The results from this study suggest that the differential histone acetylation in the different sub-regions of the BNST following fear learning and its extinction may be responsible for changes in the neuronal activation patterns resulting in either fear or less fear.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
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