정신분열병 환자에서 세가지 청각 자극“Oddball” 모형에 의한 사건관련전위 P3a와 P3b

• 영문명: Event-Related Potential P3a and P3b using 3-Stimulus Auditory “Oddball” Paradigm in the Patients with Schizophrenia
• 발행기관: 대한신경정신의학회
• 저자명: 진용탁 박이진 남지민 한상익 전양환
• 간행물 정보: 『신경정신의학』제44권 제5호, 568~575쪽, 전체 8쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2005.09.30

영문 초록

Objectives：Using 3-stimulus auditory “oddball” paradigm reflecting fronto/central and temporo/parietal functions simultaneously, we examined patients with schizophrenia. Methods：Fifteen patients with schizophrenia from outpatient clinic and fifteen normal controls from hospital staffs were recruited for the study. To elicit P3a and P3b, 3-stimulus auditory oddball paradigm was employed. The 3-stimulus auditory oddball paradigm was composed of standard tone (1,000 Hz, 75 dB, 80%), target tone (2,000 Hz, 75 dB, 10%) and distracte (White noise, 95 dB, 10%). Results：P3a and P3b were prominent in fronto/central and temporo/parietal areas, respectively, in both schizophrenics and normal controls. The P300 amplitude in patients with schizophrenia was reduced across P3a and P3b (p<0.01). The P300 latency in patients with schizophrenia was delayed across P3a and P3b (p<0.01). Conclusion：These results were consistent with frontal and temporo-parietal lobe dysfunctions in schizophrenics. The 3- stimulus auditory paradigm could be applied for patients with schizophrenia and useful for further exploration the disorder

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키워드

P300 P3a P3b Schizophrenia 3-stimulus auditory paradigm