정신분열병환자의 뇌량에 대한 신경병리적 고찰： 확산텐서영상(Diffusion Tensor Image)기법의 적용

• 영문명: The Contemplation of Neuropathological Abnormalities of the Corpus Callosum in Schizophrenia：A Diffusion Tensor Imaging Study
• 발행기관: 대한신경정신의학회
• 저자명: 이경진 신용욱 하태현 이종민 김인영 김선일 문원진 정은철 박해정 오정은 박지영 강경훈 권기원 권준수
• 간행물 정보: 『신경정신의학』제44권 제4호, 432~438쪽, 전체 7쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2005.07.30

영문 초록

Objectives：Diffusion tensor imaging (DTI) is a new technique that can be used to visualize and measure the diffusion of water in brain tissue. It is particularly useful for evaluating white matter abnormalities. In this paper, we investigated the neuropathology of the corpus callosum in patients with schizophrenia through the new methods, diffusion tensor imaging. Methods：Diffuse tensor imaging was performed in 19 schizophrenic patients and 26 healthy controls. One complementary measure, fractional anisotropy (FA), which is considered to be sensitive indices of axonal integrity, was obtained from regions of interest in the five areas of the corpus callosum. Neuropsychological measurement also underwent for measurement of frontal lobe function in two groups. Results：There were no significant differences of FA in the DTI measures for either the schizophrenic patients compared with controls. FA was significantly decreased in women compared with men. Neuropsychological measurements such as Wisconsin card sorting test were correlated with FA of patients with schizophrenia. Conclusion：FA measures revealed no differences between schizophrenia and controls. The findings suggest that the structural integrity of white matter in patient with schizophrenia was not disrupted. The results are discussed in relation to previous studies reporting positive and negative findings. It is concluded that further studies using DTI in larger samples, improved and standardized methods of data acquisition and analysis are needed.

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키워드

Schizophrenia Corpus callosum Diffusion tensor imaging Fractional anisotropy