정상인에서 양가감정과 관련된 뇌 영역：양전자방출단층촬영 상관 연구

• 영문명: Brain Regions Associated with Ambivalence in Healthy Adults：A PET Correlation Study
• 발행기관: 대한신경정신의학회
• 저자명: 정영철 석정호 전지원 박해정 이종두 김재진
• 간행물 정보: 『신경정신의학』제45권 제3호, 191~198쪽, 전체 8쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2006.05.30

영문 초록

Objectives：The present study investigated the brain regions that correlate with ambivalence in schizotypy, a latent personality organization that is proposed to precede and contribute to the liability of developing schizophrenia. Methods：Using 18F-FDG PET scan, we investigated the brain activity of twenty one normal healthy subjects during the resting state. Questionnaires, including the Korean Version of Schizotypal Ambivalence Scale (K-SAS), were administrated after the scan in order to assess the self-rated individual differences in ambivalence. Results：The Schizotypal Ambivalence Scale (SAS) scores showed positive correlation with the metabolic rates in the left parahippocampal gyrus and the fornix. In contrast, the Ambivalence over Expression of Emotion Questionnaire (AEQ) scores showed negative correlation with the metabolic rates in the right putamen. Although scores of the two ambivalence scales correlated positively (Pearson correlation coefficient 0.477, p<0.050), there was no substantial overlap between the neural correlates. Conclusion：This study suggests that the hippocampal complex, which dysfunction has been reported to correlate with impaired information processing in schizophrenia, may underlie schizotypal ambivalence.

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키워드

18F-FDG PET Schizotypal ambivalence Hippocampus