Microstructural Abnormalities of Basal Ganglia and Thalamus in Bipolar and Unipolar Disorders: A Diffusion Kurtosis and Perfusion Imaging Study

• 발행기관: 대한신경정신의학회
• 저자명: Lianping Zhao Ying Wang Yanbin Jia Shuming Zhong Yao Sun Zhifeng Zhou Zhongping Zhang Li Huang
• 간행물 정보: 『Psychiatry Investigation』제14권 제4호, 471~482쪽, 전체 12쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2017.07.31

영문 초록

Objective-Bipolar disorder (BD) is often misdiagnosed as unipolar depression (UD), leading to mistreatment and poor clinical outcomes. However, little is known about the similarities and differences in subcorticalgray matter regions between BD and UD. Methods-Thirty-five BD patients, 30 UD patients and 40 healthy controls underwent diffusional kurtosis imaging (DKI) and three dimensional arterial spin labeling (3D ASL). The parameters including mean kurtosis (MK), axial kurtosis (Ka), radial kurtosis (Kr), fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (Da), radial diffusivity (Dr) and cerebral blood flow (CBF) were measured by using regions-of-interest analysis in the caudate, putamen and thalamus of the subcortical gray matter regions. Results-UD exhibited differences from controls for DKI measures and CBF in the left putamen and caudate. BD showed differences from controls for DKI measures in the left caudate. Additionally, BD showed lower Ka in right putamen, higher MD in right caudate compared with UD. Receiver operating characteristic analysis revealed the Kr of left caudate had the highest predictive power for distinguishing UD from controls. Conclusion-The two disorders may have overlaps in microstructural abnormality in basal ganglia. The change of caudate may serve as a potential biomarker for UD.

목차

INTRODUCTION

METHODS

RESULTS

DISCUSSION

SUPPLEMENTARY MATERIALS

ACKNOWLEDGEMENTS

REFERENCES

키워드

Bipolar disorder Depressive disorder Major Brain imaging/neuroimaging Diffusion Perfusion imaging