양극성 장애에서 발병 연령에 따른 증상 및 예후의 차이：전향적 1년 추적 연구

• 영문명: Clinical Features and Prognosis Related to Age at Onset in Bipolar Disorder： A Prospective 1 Year Follow-Up
• 발행기관: 대한신경정신의학회
• 저자명: 나경세 김용구
• 간행물 정보: 『신경정신의학』제46권 제2호, 122~128쪽, 전체 7쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2007.03.30

영문 초록

Objectives：There have been several studies demonstrating that age at onset is associated with clinical and functional outcome in bipolar disorder. The purpose of this study was to investigate whether age at onset would influence on the prognosis of patients with bipolar I disorder in a Korean sample. Methods：Thirty-one patients with bipolar I disorder (DSM-IV) were recruited. Age at onset was split at age 30 years into early onset (n=15) and late onset (n=16) groups. These patients were followed at 1 year to assess re-hospitalization, psychiatric symptoms (Brief Psychiatric Rating Scale, Young Mania Rating Scale), and social functioning (Korean version of the Social Adjustment Scale II revised version：KSAS II-RV). The subgroups were compared by Mann-Whitney U test and chi-square test. Results：Early onset group had more psychotic symptoms at hospitalization (χ2=5.743, p=.029) and had more KSAS IIRV score after 1 year (U=49.000, p=.004). Other psychiatric symptoms except psychosis were not significantly different between early onset and late onset group. KSAS II-RV score was not significantly correlated with BPRS and YMRS score. Conclusion：Our data suggest that early onset group may have poorer social functioning than late onset group in bipolar I disorder.

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키워드

Age at onset Bipolar disorder Course Outcome Relapse Social adjustment scale