Tourette 장애 소년에서 자기공명영상을 이용한 기저핵의 용적 분석

• 영문명: The Volumetric MRI Analysis of the Basal Ganglia in Boys with Tourette’s Disorder
• 발행기관: 대한신경정신의학회
• 저자명: 선우영경 신용범 이명지 김지영 배재남 강민희 김철응 이정섭
• 간행물 정보: 『신경정신의학』제47권 제4호, 311~317쪽, 전체 7쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2008.07.30

영문 초록

Objectives：The purpose of this study was to investigate the regional differences of the basal ganglia volume between the boy subjects who have Tourette’s disorder and the control group who don’t have this disorder by using Brain MRI. Methods：Sixteen subjects who were diagnosed as Tourette’s disorder using DSM-IV criteria, and sixteen healthy subjects were selected. For analysis the coronal slice images of the basal ganglia were collected and collected MR images were analyzed with NIH Image (version 6.1 ppc). Results：The total brain volume in the subjects with Tourette’s disorder were smaller than control group by 6.2% (F=6.2,d.f.=1, p=0.019). The right putamen volume in boys with Tourette’s disorder were significant smaller than control group statistically (F=3.2, d.f.=3, p=0.040). The asymmetry (left>right) in the globus pallidus decreased significantly in the boys with Tourette’s disorder (p=0.06) were found from this experiment. Conclusion：These findings suggest that boys with Tourette’s disorder may have neuropathological abnormalities in the basal ganglia. Moreover, the present findings point out the important role of basal ganglia, especially putamen, in pathophysiology of Tourette’s disorder. More studies about the structural and functional analysis of the basal ganglia in Tourette’s disorder are highly required.

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키워드

Tourette’s disorder Basal ganglia Putamen Globus pallidus