양극성 장애의 신경인지기능

• 영문명: Neurocognitive Functioning in Bipolar Disorder
• 발행기관: 대한신경정신의학회
• 저자명: 고진경 김병수 김창윤 주연호
• 간행물 정보: 『신경정신의학』제47권 제2호, 134~141쪽, 전체 8쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2008.03.30

영문 초록

Objectives：This study was aimed to investigate the neurocognitive functioning of patients with remitted bipolar disorder and compare with schizophrenic patients’ neurocognitive functioning. Methods：This issue was addressed by comparing remitted DSM-IV diagnosed bipolar, schizophrenics patients and controls on several clinical and neurocognitive measures. Clinical state was assessed using the Positive and Negative Syndrome Scale (PANSS), Young Mania Rating Scale (YMRS), and Montgomery-Asberg Depression Rating Scale (MADRS). Neurocognitive measures included the KWIS, WMS-III, Korean California Verbal Learning Test (K-CVLT), Wisconsin Card Sorting Test (WCST), Rey-Osterrieth Complex Test (RCFT), and Color Trails Test (CTT). Thirty-two subjects with remitted bipolar disorder, twenty-four remitted schizophrenia and twelve normal controls were studied. Results：Analysis of variance (ANOVA) revealed no differences across groups on age, education and IQ. With respect to neurocognitive test performance, bipolar disorder patients and schizophrenic patients were similar and both groups were impaired compared to normal controls. Two diagnosed groups have persistent impairments in neurocognitive function, particularly in the domains of declarative memory. Conclusion：The results provide support for the view that remitted patients with bipolar disorder suffer cognitive impairment

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키워드

Bipolar disorder Schizophrenia Neurocognitive deficits Specificity