강박장애환자에서 세로토닌 효현제인 MK-212가 체온 및 신경내분비 반응에 미치는 효과

• 영문명: The Effect of MK-212, a Serotonin Agonist, on Body Temperature and Neuroendocrine Responses in Obsessive-Compulsive Disorder
• 발행기관: 대한신경정신의학회
• 저자명: 이홍식 김찬형 송동호
• 간행물 정보: 『신경정신의학』제33권 제2호, 420~427쪽, 전체 8쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1994.03.30

영문 초록

Objects : This study was designed to further examine the serotonergic system in Obsessive- Compulsive Disorder(OCD). Methods : The plasma concentrations of prolactin and cortisol as well as body temperature responses following the oral administration of MK-212(6-chloro-2-[ 1 -piperazinyll-pyrazine), a serotonin agonist, and placebo, were studied in 15 patients with OCD and 13 healthy subjects. Results: The two groups did not differ significantly in basal body temperature, plasma prolactin or cortisol levels. Both the prolactin and body temperature responses to oral administration of MK212(20mg) were significantly blunted in the patients with OCD as compared to those of healthy subjects. Conclusion : These findings are consistent with previous reports of decreased serotonergic responsivity in OCD.

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키워드

Obsessive-compulsive disorder MK-212 Body temperature Neuroendocrine response