만성 정신분열증 환자에서 항정신병 약물의 병용제로서 투여한 Glycine의 임상적 효과에 관한 연구

• 영문명: Clinical Effect of Glydne as Adjuvant to Antipsychotics in Chronic Schizophrenics
• 발행기관: 대한신경정신의학회
• 저자명: 최시영 신영민 김용식
• 간행물 정보: 『신경정신의학』제34권 제2호, 411~418쪽, 전체 8쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1995.03.30

영문 초록

Objects : This study was undertaken to know whether there is any clinical efficacy o f glycine as adjuvant to antipsychotics in chronic schizophrenics. Methods : Twenty two chronic schizophrenic patients, to whom the same antipsychotics as usual were administered, were random ly assigned to two groups ; to the experimental group, glycine was and to the controlled group, placebo was administered adjuntively for 12 weeks in double blind design. We assessed psychopathology by BPRS and measured plasm a concentration of glycine, serine, taurine, by H PLC every 4 weeks. Results : 1) The experimental group showed no significant psychopathological improvement, comparing with the controlled group (Table 2-a). 2) The concentration of glycine in the experimental group was significantly increased than the controlled group (Table 3-a). 3) Specific side effects o f glycine were not found. Conclusions * Based on these results, glycine adjuvant therapy to chronic schizophrenics is thought to be little effect on improvement of schizophrenic symtoms.

목차

서 론

연구대상 및 방법

결 과

고 찰

요 약

참 고 문 헌

키워드

Glycine Chronic schizophrenia