부신절제가 전기경련 충격에 의한 흰쥐 뇌의 조기유전자 발현에 미치는 영향

• 영문명: The Effect of Adrenalectomy on the Induction of Immediate Early Genes by Electroconvulsive Shock in Rat Brain
• 발행기관: 대한신경정신의학회
• 저자명: 하규섭 강웅구 정화연 주연호 박주배 김용식
• 간행물 정보: 『신경정신의학』제35권 제4호, 936~947쪽, 전체 12쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1996.07.30

영문 초록

The adrenocortical hormones have been known to be related with the pathogenesis of mental disorders and individual vulnerability to stress. To evaluate the influences of adrenocortical hormone on the signal transduction system in rat brain, the authors observed the effects of bilateral adrenalectomy on the induction of immediate early genes(IEGs) after electroconvulsive shock(ECS). Male Sprague-Dawley rats(200 - 250g) were treated with ECS(130V，O.Ssec) at day 3 after bilateral adrenalectomy. Rats were sacrificed at 0, 15，30, 45, and 60 minutes after ECS, and cerebral cortex, hippocampus, and cerebellum were dissected from the brain. The induction of IEGs was assessed with northern hybridization. The band intensities of the autoradiographs measured with densitometer were compared between adrenalectomized group and shamoperated control group. After adrenalectomy, the c-fos, jun B, and TIS 1 induction by ECS was generally attenuated in the cerebral cortex. The induction of IEGs in the hippocampus and in the cerebellum was not influenced by adrenalectomy. These results suggest that adrenalectomy has differential influences on the induction of IEGs by ECS in the rat brain depending on the region of brain

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Adrenalectomy Adrenocortical hormone Electroconvulsive shock Immediate early gene Signal transduction system.